Protein Name:
Sorting nexin-27
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UniprotKB/SwissProt ID: Q96L92 (Q96L92)
Gene Name:
SNX27
Organism: Homo sapiens (Human)
Function: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome membrane. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96L92
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
354 |
QNYTSAVPGT C LTIRKWLFTT |
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| 2 |
421 |
MVMYLNMLRT C EGYNEIIFPH |
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