Protein Name:
tRNA N(3)-cytidine methyltransferase METTL2A
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UniprotKB/SwissProt ID: Q96IZ6 (Q96IZ6)
Gene Name:
METTL2A
Organism: Homo sapiens (Human)
Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96IZ6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
126 |
FLENKSEVPE C RNNEDGPGLI |
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| 2 |
171 |
VTQKISDLEI C ADEFPGSSAT |
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