Protein Name:
RCC1-like G exchanging factor-like protein
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UniprotKB/SwissProt ID: Q96I51 (Q96I51)
Gene Name:
RCC1L
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (PubMed:27667664) Plays an essential role in mitochondrial ribosome biogenesis via its association with GTPases that play a role in the assembly of the large ribosome subunit Plays an essential role in mitochondrial ribosome biogenesis via its association with GTPases that play a role in the assembly of the small ribosome subunit
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion membrane. Mitochondrion inner membrane. Mitochondrion inner membrane. Mitochondrion inner membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96I51
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
181 |
PQETRVLQVS C GRAHSLVLTD |
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| 2 |
206 |
FSMGNNSYGQ C GRKVVENEIY |
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