Protein Name:
ERO1-like protein alpha
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UniprotKB/SwissProt ID: Q96HE7 (Q96HE7)
Gene Name:
ERO1A
Organism: Homo sapiens (Human)
Function: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins (PubMed:29858230). Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Golgi apparatus lumen. Secreted. Cell projection, dendrite
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96HE7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
104 |
CGRRDCAVKP C QSDEVPDGIK |
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| 2 |
131 |
SEEANNLIEE C EQAERLGAVD |
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| 3 |
166 |
TKHDDSSDNF C EADDIQSPEA |
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| 4 |
208 |
KIWNVIYEEN C FKPQTIKRPL |
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| 5 |
85 |
RYYKVNLKRP C PFWNDISQCG |
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| 6 |
99 |
NDISQCGRRD C AVKPCQSDEV |
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