Protein Name:
PDZ and LIM domain protein 5
|
UniprotKB/SwissProt ID: Q96HC4 (Q96HC4)
Gene Name:
PDLIM5
Organism: Homo sapiens (Human)
Function: May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Postsynaptic density. Presynapse. Postsynapse. Cytoplasm, cytosol
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q96HC4
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
213 |
VPRQPTVTSV C SETSQELAEG |
CCCEEEEEEC C CCCCEEECCC |
2.81% |
22178444
|
| 2 |
467 |
GFVEEKGALY C ELCYEKFFAP |
CCCEEEEEEC C CCCCEEECCC |
3.15% |
|
| 3 |
479 |
LCYEKFFAPE C GRCQRKILGE |
CCCEEEEEEC C CCCCEEECCC |
3.97% |
|
| 4 |
73 |
HLEAQNKIKG C TGSLNMTLQR |
CCCEEEEEEC C CCCCEEECCC |
3.11% |
|
|
