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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Methylthioribulose-1-phosphate dehydratase

UniprotKB/SwissProt ID: Q96GX9 (Q96GX9)

Gene Name: APIP

Organism: Homo sapiens (Human)

Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001303 Aldolase_II/adducin_N
IPR036409 Aldolase_II/adducin_N_sf
IPR017714 MethylthioRu-1-P_deHdtase_MtnB
IPR027514 Salvage_MtnB_euk

The S-nitrosylation sites of Q96GX9

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 188 AHAMNEYPDS C AVLVRRHGVY   
2 76 ERIQPEDMFV C DINEKDISGP   
3 97 SPSKKLKKSQ C TPLFMNAYTM