Protein Name:
Nuclear receptor-binding factor 2
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UniprotKB/SwissProt ID: Q96F24 (Q96F24)
Gene Name:
NRBF2
Organism: Homo sapiens (Human)
Function: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96F24
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
155 |
LQQKSEPAEP C IGSKAPKDDK |
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