Protein Name:
DnaJ homolog subfamily A member 3, mitochondrial
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UniprotKB/SwissProt ID: Q96EY1 (Q96EY1)
Gene Name:
DNAJA3
Organism: Homo sapiens (Human)
Function: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix. Cytoplasm, cytosol. Postsynaptic cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96EY1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
236 |
KEFTVNIMDT C ERCNGKGNEP |
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| 2 |
292 |
GSIIISPCVV C RGAGQAKQKK |
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