Protein Name:
Pyrroline-5-carboxylate reductase 2
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UniprotKB/SwissProt ID: Q96C36 (Q96C36)
Gene Name:
PYCR2
Organism: Homo sapiens (Human)
Function: Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:23024808, PubMed:2722838, PubMed:6894153). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:23024808, PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492). In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+) (PubMed:2722838, PubMed:6894153)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96C36
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
225 |
KMLLDSEQHP C QLKDNVCSPG |
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| 2 |
262 |
SLLINAVEAS C IRTRELQSMA |
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37478858
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| 3 |
95 |
DVQARHIVVS C AAGVTISSVE |
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