Protein Name:
Protein phosphatase 1 regulatory inhibitor subunit 16B
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UniprotKB/SwissProt ID: Q95N27 (Q95N27)
Gene Name:
PPP1R16B
Organism: Bos taurus (Bovine)
Function: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of the PI3K/AKT signaling pathway (By similarity). Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (PubMed:26806547). Involved in the regulation of endothelial cell filopodia extension (PubMed:17609201). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity). Involved in the dephosphorylation of EEF1A1 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell membrane. Nucleus. Cell projection
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Graphical Visualization of S-nitrosylation Sites:
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