UniprotKB/SwissProt ID: Q94AH9 (Q94AH9)
Gene Name:
FIB2
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (Probable). Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (Probable). Site specificity is provided by a guide RNA that base pairs with the substrate (Probable). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (Probable). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity). Acts as a negative regulator of expression of immune responsive genes, including pathogenesis-related gene 1 (PR1), and of resistance against bacterial pathogen (PubMed:30307032). Binds to MED19A, a positive regulator of PR1 expression, to repress the activator activity of MED19A (PubMed:30307032). In response to the bacterial pathogen-associated molecular pattern (PAMP) elf18, associates with the long non-coding RNA (lncRNA) ELENA1 (At4g16355), and releases its repression of MED19A (PubMed:30307032). Possesses ribonuclease activity toward rRNA in vitro (PubMed:29163603). Binds phosphoinositides, phospholipids and phosphatidic acid in vitro (PubMed:29163603)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus
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