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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Phosphoethanolamine N-methyltransferase 2

UniprotKB/SwissProt ID: Q944H0 (Q944H0)

Gene Name: NMT2

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Catalyzes N-methylation of phosphomonomethylethanolamine and phosphodimethylethanolamine, the two methylation steps required to convert phosphomonoethanolamine to phosphocholine (PubMed:20650897). Unlike NMT1, NMT2 cannot utilize phosphoethanolamine as substrate in vitro (PubMed:20650897). In association with NMT1, involved in the production of phosphatidylcholine in roots, essential for root development (PubMed:30518673). In association with NMT1 produce phosphocholine mainly for leaf growth maintenance (PubMed:35560207) Catalyzes the N-methylation of phosphoethanolamine to phosphomonomethylethanolamine in vitro

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR025714 Methyltranfer_dom
IPR041698 Methyltransf_25
IPR025771 Phosphoethanolamine_N-MeTrfase
IPR029063 SAM-dependent_MTases_sf

The S-nitrosylation sites of Q944H0

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 105 NGHYKNIKFM C ADVTSPDLKI   
2 160 PGGYIFFRES C FHQSGDSKRK