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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: DNA mismatch repair protein PMS1

UniprotKB/SwissProt ID: Q941I6 (Q941I6)

Gene Name: PMS1

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates. Does not seem to be required for homologous somatic recombination

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR014762 DNA_mismatch_repair_CS
IPR013507 DNA_mismatch_S5_2-like
IPR036890 HATPase_C_sf
IPR002099 MutL/Mlh/PMS
IPR038973 MutL/Mlh/Pms-like
IPR014790 MutL_C
IPR042120 MutL_C_dimsub
IPR042121 MutL_C_regsub
IPR037198 MutL_C_sf
IPR020568 Ribosomal_Su5_D2-typ_SF
IPR014721 Ribsml_uS5_D2-typ_fold_subgr

The S-nitrosylation sites of Q941I6

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 656 RLQSTGYVSK C MNTPQPKKCF