Protein Name:
SWI/SNF complex subunit SMARCC1
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UniprotKB/SwissProt ID: Q92922 (Q92922)
Gene Name:
SMARCC1
Organism: Homo sapiens (Human)
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q92922
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
108 |
NPAFTKLPAK C FMDFKAGGAL |
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| 2 |
164 |
NIEKTLVQNN C LTRPNIYLIP |
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| 3 |
511 |
NPQEYLTSTA C RRNLTGDVCA |
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| 4 |
520 |
ACRRNLTGDV C AVMRVHAFLE |
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| 5 |
657 |
EHVGSRTQDE C ILHFLRLPIE |
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| 6 |
761 |
VDPTYGLESS C IAGTGPDEPE |
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| 7 |
845 |
TEENKELTDT C KERESDTGKK |
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