Protein Name:
Rho guanine nucleotide exchange factor 1
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UniprotKB/SwissProt ID: Q92888 (Q92888)
Gene Name:
ARHGEF1
Organism: Homo sapiens (Human)
Function: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q92888
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
537 |
KAKQRKDPRF C AFVQEAESRP |
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| 2 |
595 |
REKVELAAEC C REILHHVNQA |
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| 3 |
892 |
KQLEELEEEF C RLRPLLSQLG |
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| 4 |
911 |
LGGNSVPQPG C T--------- |
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