Protein Name:
Signal transducing adapter molecule 1
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UniprotKB/SwissProt ID: Q92783 (Q92783)
Gene Name:
STAM
Organism: Homo sapiens (Human)
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (Microbial infection) Plays an important role in Dengue virus entry
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Early endosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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