Protein Name:
CCR4-NOT transcription complex subunit 9
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UniprotKB/SwissProt ID: Q92600 (Q92600)
Gene Name:
CNOT9
Organism: Homo sapiens (Human)
Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm, P-body
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q92600
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
167 |
FLLTTEIIPL C LRIMESGSEL |
CCCCCCCCCC C CCHHHCCHHH |
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| 2 |
91 |
TLTAHQSNRV C NALALLQCVA |
CCCCCCCCCC C CCHHHCCHHH |
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19483679
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| 3 |
99 |
RVCNALALLQ C VASHPETRSA |
CCCCCCCCCC C CCHHHCCHHH |
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19483679
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