Protein Name:
Heat shock protein 105 kDa
|
UniprotKB/SwissProt ID: Q92598 (Q92598)
Gene Name:
HSPH1
Organism: Homo sapiens (Human)
Function: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q92598
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
140 |
ENSLKKPVTD C VISVPSFFTD |
|
|
|
| 2 |
167 |
LDAAQIVGLN C LRLMNDMTAV |
|
|
|
| 3 |
245 |
NFDEKLVEHF C AEFKTKYKLD |
|
|
|
| 4 |
290 |
NSTDLPLNIE C FMNDKDVSGK |
|
|
|
| 5 |
310 |
KMNRSQFEEL C AELLQKIEVP |
|
|
|
| 6 |
34 |
ETIANEFSDR C TPSVISFGSK |
|
|
|
| 7 |
376 |
LNADEAVARG C ALQCAILSPA |
|
|
|
| 8 |
380 |
EAVARGCALQ C AILSPAFKVR |
|
|
|
| 9 |
516 |
NEMSSEADME C LNQRPPENPD |
|
|
|
| 10 |
650 |
EYVYEFRDKL C GPYEKFICEQ |
|
|
|
| 11 |
658 |
KLCGPYEKFI C EQDHQNFLRL |
|
|
37478858
|
| 12 |
796 |
KTKIKELNNT C EPVVTQPKPK |
|
|
|
|
