Protein Name:
Transmembrane 9 superfamily member 4
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UniprotKB/SwissProt ID: Q92544 (Q92544)
Gene Name:
TM9SF4
Organism: Homo sapiens (Human)
Function: Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Golgi apparatus. Early endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q92544
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
227 |
EDLKADEKSS C TLPEGTNSSP |
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