UniprotKB/SwissProt ID: Q92542 (Q92542)
Gene Name:
NCSTN
Organism: Homo sapiens (Human)
Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Cytoplasmic vesicle membrane. Melanosome
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