Protein Name:
NAD(P)H oxidoreductase RTN4IP1, mitochondrial
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UniprotKB/SwissProt ID: Q924D0 (Q924D0)
Gene Name:
Rtn4ip1
Organism: Mus musculus (Mouse)
Function: NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway (PubMed:37884807). Required for the O-methyltransferase activity of COQ3 (By similarity). Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro (By similarity). However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo (By similarity). May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267). Appears to be a potent inhibitor of regeneration following spinal cord injury (PubMed:12067236)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix. Mitochondrion outer membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q924D0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
130 |
GRDVSGVVME C GLDVKYFQPG |
CCCCCHHHHH H HHHHHHHHHH |
3.37% |
21278135
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| 2 |
236 |
KAWGAHVTAV C SKDASELVRK |
CCCCCHHHHH H HHHHHHHHHH |
3.77% |
21278135
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