Protein Name:
cGMP-dependent 3',5'-cyclic phosphodiesterase
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UniprotKB/SwissProt ID: Q922S4 (Q922S4)
Gene Name:
Pde2a
Organism: Mus musculus (Mouse)
Function: cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:21724846). Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity) Regulates mitochondrial cAMP levels and respiration (PubMed:21724846). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Mitochondrion matrix. Mitochondrion inner membrane. Mitochondrion outer membrane. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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