Protein Name:
Mitochondrial amidoxime reducing component 2
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UniprotKB/SwissProt ID: Q922Q1 (Q922Q1)
Gene Name:
Mtarc2
Organism: Mus musculus (Mouse)
Function: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Peroxisome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q922Q1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
274 |
EMKRVLSCPR C VLTTVDPDTG |
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| 2 |
74 |
PIKSCKGVSV C ETECTDMGLR |
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