Protein Name:
C-1-tetrahydrofolate synthase, cytoplasmic
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UniprotKB/SwissProt ID: Q922D8 (Q922D8)
Gene Name:
Mthfd1
Organism: Mus musculus (Mouse)
Function: Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate. These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q922D8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
143 |
GKLARGDLND C FIPCTPKGCL |
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| 2 |
152 |
DCFIPCTPKG C LELIKEAGVQ |
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| 3 |
785 |
REHGAFDAVK C THWAEGGQGA |
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| 4 |
863 |
TKQGFGNLPI C MAKTHLSLSH |
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