Protein Name:
ADP-ribose glycohydrolase MACROD1
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UniprotKB/SwissProt ID: Q922B1 (Q922B1)
Gene Name:
Macrod1
Organism: Mus musculus (Mouse)
Function: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q922B1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
114 |
SDKQREEHYF C KDFIKLKKIP |
CCHHHHHHHH H HHHHHHHCEE |
3.05% |
21278135
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| 2 |
184 |
SLLGGGGVDG C IHRAAGSLLT |
CCHHHHHHHH H HHHHHHHCEE |
1.73% |
21278135
|
| 3 |
197 |
RAAGSLLTDE C RTLQNCETGK |
CCHHHHHHHH H HHHHHHHCEE |
4.48% |
|
| 4 |
203 |
LTDECRTLQN C ETGKAKITCG |
CCHHHHHHHH H HHHHHHHCEE |
2.98% |
21278135
|
| 5 |
212 |
NCETGKAKIT C GYRLPAKYVI |
CCHHHHHHHH H HHHHHHHCEE |
5.26% |
21278135
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| 6 |
244 |
TASQAAELRS C YLSSLDLLLE |
CCHHHHHHHH H HHHHHHHCEE |
2.99% |
21278135
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| 7 |
264 |
EHRLRSVAFP C ISTGVFGYPN |
CCHHHHHHHH H HHHHHHHCEE |
2.87% |
21278135
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