Protein Name:
TAR DNA-binding protein 43
|
UniprotKB/SwissProt ID: Q921F2 (Q921F2)
Gene Name:
Tardbp
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (By similarity). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (By similarity). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm, Stress granule. Mitochondrion
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q921F2
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
173 |
SQRHMIDGRW C DCKLPNSKQS |
CCCCEEEECC C CCCCCCCCCC |
4.19% |
20925432
|
| 2 |
244 |
FADDKVAQSL C GEDLIIKGIS |
CCCCEEEECC C CCCCCCCCCC |
7.31% |
|
| 3 |
39 |
STVTAQFPGA C GLRYRNPVSQ |
CCCCEEEECC C CCCCCCCCCC |
6.99% |
|
| 4 |
50 |
GLRYRNPVSQ C MRGVRLVEGI |
CCCCEEEECC C CCCCCCCCCC |
1.24% |
|
|
