Protein Name:
Prolow-density lipoprotein receptor-related protein 1
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UniprotKB/SwissProt ID: Q91ZX7 (Q91ZX7)
Gene Name:
Lrp1
Organism: Mus musculus (Mouse)
Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development (PubMed:1423604). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an alpha-2-macroglobulin receptor (By similarity). Acts as a TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (By similarity). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (By similarity) (Microbial infection) Functions as a receptor for Vibrio cholerae cholix toxin and for Pseudomonas aeruginosa exotoxin A
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Membrane, coated pit. Cell membrane. Membrane, coated pit. Golgi outpost. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q91ZX7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1076 |
DEFQCRLDGL C IPLRWRCDGD |
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| 2 |
1098 |
DCMDSSDEKS C EGVTHVCDPN |
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| 3 |
1564 |
CLINYNRTVS C ACPHLMKLHK |
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| 4 |
2518 |
GGRILQEDFT C RAVNSSCRAQ |
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| 5 |
2697 |
RDCPGVKRPR C PLNYFACPSG |
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| 6 |
2704 |
RPRCPLNYFA C PSGRCIPMSW |
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| 7 |
2953 |
NECLSRKLSG C SQDCEDLKIG |
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| 8 |
3006 |
LCINTHGSYK C LCVEGYAPRG |
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| 9 |
3316 |
CLLSPGGGHK C ACPTNFYLGG |
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| 10 |
3823 |
GFHTVPGQPG C QDINECLRFG |
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| 11 |
808 |
AQQQQVGTNK C RVNNGGCSSL |
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