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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ras-related protein Rab-4B

UniprotKB/SwissProt ID: Q91ZR1 (Q91ZR1)

Gene Name: Rab4b

Organism: Mus musculus (Mouse)

Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14697203). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (PubMed:14697203)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Early endosome membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR027417 P-loop_NTPase
IPR041819 Rab4
IPR050209 Rab_GTPases_membrane_traffic
IPR005225 Small_GTP-bd
IPR001806 Small_GTPase

The S-nitrosylation sites of Q91ZR1

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 119 LASPNIVVIL C GNKKDLDPER   
2 23 VIGSAGTGKS C LLHQFIENKF