Protein Name:
UDP-N-acetylhexosamine pyrophosphorylase
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UniprotKB/SwissProt ID: Q91YN5 (Q91YN5)
Gene Name:
Uap1
Organism: Mus musculus (Mouse)
Function: Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (By similarity). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (By similarity). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection (PubMed:36603579). Regulates innate immunity by catalyzing pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (By similarity) Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P) Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q91YN5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
293 |
TNPTEPVGVV C RVDGVYQVVE |
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