Protein Name:
Argininosuccinate lyase
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UniprotKB/SwissProt ID: Q91YI0 (Q91YI0)
Gene Name:
Asl
Organism: Mus musculus (Mouse)
Function: Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (By similarity). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q91YI0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
129 |
TDLRLWMRQT C SKLSALLRVL |
CCCCCCCCCC C CCCCCHHHHH |
2.27% |
22178444
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| 2 |
307 |
RSKAGRVFGR C AGLLMTLKGL |
CCCCCCCCCC C CCCCCHHHHH |
3.44% |
22178444
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