Protein Name:
Fructose-bisphosphate aldolase B
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UniprotKB/SwissProt ID: Q91Y97 (Q91Y97)
Gene Name:
Aldob
Organism: Mus musculus (Mouse)
Function: Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:25637246). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q91Y97
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
135 |
IQGLDGLSER C AQYKKDGVDF |
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| 2 |
158 |
WRAVLRIADQ C PSSLAIQENA |
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| 3 |
269 |
RTVPAAVPGI C FLSGGMSEED |
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| 4 |
336 |
EAFMKRAMAN C QAAQGQYVHT |
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