Protein Name:
Glucokinase regulatory protein
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UniprotKB/SwissProt ID: Q91X44 (Q91X44)
Gene Name:
Gckr
Organism: Mus musculus (Mouse)
Function: Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:10713097). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10713097). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q91X44
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
559 |
SNDVRAAPIS C HVQVAHEKEK |
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