Protein Name:
Kynurenine 3-monooxygenase
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UniprotKB/SwissProt ID: Q91WN4 (Q91WN4)
Gene Name:
Kmo
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q91WN4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
139 |
KVHFGHKLSK C IPEEGVLTVL |
CCCCCCCCCE E EEECCHHHHH |
5.88% |
22178444
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| 2 |
299 |
KCSPFHLKSH C VLMGDAAHAI |
CCCCCCCCCE E EEECCHHHHH |
3.03% |
22178444
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