Protein Name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
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UniprotKB/SwissProt ID: Q91WD5 (Q91WD5)
Gene Name:
Ndufs2
Organism: Mus musculus (Mouse)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:26437605, PubMed:29887397, PubMed:31297047, PubMed:38575788). Essential for the catalytic activity and assembly of complex I (PubMed:26437605, PubMed:29887397, PubMed:31297047). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174). Plays an important role in carotid body sensing of hypoxia (PubMed:26437605, PubMed:29887397). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (PubMed:31297047)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion inner membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q91WD5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
146 |
FDRLDYVSMM C NEQAYSIAVE |
CHHHHHHHHH H CCCCCEECCC |
3.67% |
21278135
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| 2 |
332 |
SRGDCYDRYL C RVEEMRQSLR |
CHHHHHHHHH H CCCCCEECCC |
3.21% |
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| 3 |
347 |
MRQSLRIIEQ C LNKMPPGEIK |
CHHHHHHHHH H CCCCCEECCC |
2.68% |
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