UniprotKB/SwissProt ID: Q91W98 (Q91W98)
Gene Name:
Slc15a4
Organism: Mus musculus (Mouse)
Function: Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:19570976, PubMed:21277849, PubMed:25238095, PubMed:27845049, PubMed:29305823). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29784761). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:19570976, PubMed:23028315, PubMed:24695226, PubMed:25238095, PubMed:29784761). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:21045126, PubMed:23382217, PubMed:25238095, PubMed:30262916). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (PubMed:25310967). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (PubMed:29155995)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome membrane. Endosome membrane. Early endosome membrane
|
|
|
