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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glycine dehydrogenase (decarboxylating), mitochondrial

UniprotKB/SwissProt ID: Q91W43 (Q91W43)

Gene Name: Gldc

Organism: Mus musculus (Mouse)

Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001597 ArAA_b-elim_lyase/Thr_aldolase
IPR003437 GcvP
IPR049316 GDC-P_C
IPR049315 GDC-P_N
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
IPR015422 PyrdxlP-dep_Trfase_small

The S-nitrosylation sites of Q91W43

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 230 KRKKFFVDPR C HPQTIAVVQT  CCHHHHHHCC C CCCCCCCCCC  7.17% 22178444
2 563 LVHSMIPLGS C TMKLNSSSEL  CCHHHHHHCC C CCCCCCCCCC  4.01%
3 762 VSHLNLHKTF C IPHGGGGPGM  CCHHHHHHCC C CCCCCCCCCC  5.98% 22178444