Protein Name:
3-oxoacyl-[acyl-carrier-protein] reductase
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UniprotKB/SwissProt ID: Q91VT4 (Q91VT4)
Gene Name:
Cbr4
Organism: Mus musculus (Mouse)
Function: Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q91VT4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
115 |
HTNLLGSMLT C KAAMKTMIQQ |
CCCEEEECCC C CHHHHHHHHH |
2.19% |
21278135
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| 2 |
5 |
------MDKV C AVFGGSRGIG |
CCCEEEECCC C CHHHHHHHHH |
3.09% |
21278135
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| 3 |
55 |
ELGGNHLAFR C DVAKEQDVQS |
CCCEEEECCC C CHHHHHHHHH |
3.89% |
21278135
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