Protein Name:
FERM, ARHGEF and pleckstrin domain-containing protein 2
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UniprotKB/SwissProt ID: Q91VS8 (Q91VS8)
Gene Name:
Farp2
Organism: Mus musculus (Mouse)
Function: Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity (PubMed:20702777, PubMed:23375260). Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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