Protein Name:
Immunity-related GTPase family Q protein
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UniprotKB/SwissProt ID: Q8WZA9 (Q8WZA9)
Gene Name:
IRGQ
Organism: Homo sapiens (Human)
Function: Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation (PubMed:39481378). Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation (PubMed:39481378). Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response (PubMed:39481378). In contrast to other members of the family, does not show GTPase activity (PubMed:39481378)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome. Cytoplasmic vesicle, autophagosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8WZA9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
152 |
AADLFVLPAN C GSSDGCEELE |
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| 2 |
328 |
ALLLPDAPLV C VRTDGEGEDP |
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| 3 |
340 |
RTDGEGEDPE C LGEGKMENPK |
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