UniprotKB/SwissProt ID: Q8WVS4 (Q8WVS4)
Gene Name:
DYNC2I1
Organism: Homo sapiens (Human)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:23910462, PubMed:25205765, PubMed:29742051, PubMed:31451806). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella (PubMed:29742051, PubMed:30320547, PubMed:30649997). Also requires to maintain a functional transition zone (PubMed:30320547)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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