Protein Name:
Solute carrier family 22 member 17
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UniprotKB/SwissProt ID: Q8WUG5 (Q8WUG5)
Gene Name:
SLC22A17
Organism: Homo sapiens (Human)
Function: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Vacuole membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8WUG5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
636 |
SLLRQPPPTR C DHVPLLATPN |
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37478858
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