Protein Name:
Ras-related protein Rab-2B
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UniprotKB/SwissProt ID: Q8WUD1 (Q8WUD1)
Gene Name:
RAB2B
Organism: Homo sapiens (Human)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, autophagosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8WUD1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
154 |
IFMETSAKTA C NVEEAFINTA |
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| 2 |
21 |
IIGDTGVGKS C LLLQFTDKRF |
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37478858
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