UniprotKB/SwissProt ID: Q8VIM4 (Q8VIM4)
Gene Name:
Bsnd
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of anion-selective CLCNKA:BSND and CLCNKB:BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (PubMed:11734858, PubMed:18833191, PubMed:21593186, PubMed:23791703). Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA:BSND and CLCNKB:BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates (PubMed:11734858, PubMed:18833191, PubMed:21593186, PubMed:23791703)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Basolateral cell membrane
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