Protein Name:
Vacuolar ATPase assembly protein VMA22
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UniprotKB/SwissProt ID: Q8VE99 (Q8VE99)
Gene Name:
Vma22
Organism: Mus musculus (Mouse)
Function: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endosome. Lysosome. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle, COPI-coated vesicle. Endoplasmic reticulum
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR040357
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Vma22/CCDC115 |
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The S-nitrosylation sites of Q8VE99
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
14 |
QALREELDSK C LQLLSDLEEL |
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