Protein Name:
Ubiquitin-like modifier-activating enzyme 5
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UniprotKB/SwissProt ID: Q8VE47 (Q8VE47)
Gene Name:
Uba5
Organism: Mus musculus (Mouse)
Function: E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:21304510). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (By similarity). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (By similarity). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (By similarity). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (By similarity). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:33372156). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (PubMed:21304510)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Golgi apparatus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8VE47
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
33 |
RTRRSGGDGH C GRTRIQEMSD |
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