Protein Name:
Sodium/potassium-transporting ATPase subunit alpha-1
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UniprotKB/SwissProt ID: Q8VDN2 (Q8VDN2)
Gene Name:
Atp1a1
Organism: Mus musculus (Mouse)
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (PubMed:17408578)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Basolateral cell membrane. Cell membrane, sarcolemma. Cell projection, axon. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8VDN2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
211 |
ADLRIISANG C KVDNSSLTGE |
CCCCCCCCCC C CCHHHCCCCC |
3.78% |
24895380
21278135
|
| 2 |
249 |
TRNIAFFSTN C VEGTARGIVV |
CCCCCCCCCC C CCHHHCCCCC |
2.74% |
24895380
22588120
21278135
|
| 3 |
374 |
VETLGSTSTI C SDKTGTLTQN |
CCCCCCCCCC C CCHHHCCCCC |
4.33% |
24895380
22588120
21278135
|
| 4 |
428 |
WFALSRIAGL C NRAVFQANQE |
CCCCCCCCCC C CCHHHCCCCC |
2.95% |
20925432
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| 5 |
459 |
GDASESALLK C IEVCCGSVME |
CCCCCCCCCC C CCHHHCCCCC |
3.02% |
20925432
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| 6 |
518 |
KGAPERILDR C SSILLHGKEQ |
CCCCCCCCCC C CCHHHCCCCC |
3.6% |
21278135
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| 7 |
606 |
RAAVPDAVGK C RSAGIKVIMV |
CCCCCCCCCC C CCHHHCCCCC |
3.23% |
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| 8 |
663 |
NQVNPRDAKA C VVHGSDLKDM |
CCCCCCCCCC C CCHHHCCCCC |
3.02% |
22178444
24895380
20925432
21278135
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| 9 |
705 |
PQQKLIIVEG C QRQGAIVAVT |
CCCCCCCCCC C CCHHHCCCCC |
1.58% |
22178444
20925432
21278135
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