Protein Name:
Deaminated glutathione amidase
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UniprotKB/SwissProt ID: Q8VDK1 (Q8VDK1)
Gene Name:
Nit1
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Possesses amidase activity toward deaminated ophthalmate in vitro (PubMed:28373563). Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8VDK1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
141 |
DWEQNQKIYN C HVLLNSKGSV |
CCCCCCCCHH H EEECCCHHCC |
1% |
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| 2 |
161 |
VVASYRKTHL C DVEIPGQGPM |
CCCCCCCCHH H EEECCCHHCC |
4.23% |
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| 3 |
63 |
TPNKQENFKT C AELVQEAARL |
CCCCCCCCHH H EEECCCHHCC |
2.6% |
21278135
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