Protein Name:
Polyprenol dehydrogenase
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UniprotKB/SwissProt ID: Q8VBZ0 (Q8VBZ0)
Gene Name:
Dhrsx
Organism: Mus musculus (Mouse)
Function: Oxidoreductase that plays a key role in early steps of protein N-linked glycosylation by mediating two non-consecutive steps in dolichol biosynthesis. Acts both as a NAD(+)-dependent dehydrogenase and as a NADPH-dependent reductase during the conversion of polyprenol into dolichol. First catalyzes the NAD(+)-dependent dehydrogenation of polyprenol into polyprenal; polyprenal is then reduced into dolichal by SRD5A3. It then catalyzes the NADPH-dependent reduction of dolichal into dolichol. May also acts as a positive regulator of starvation-induced autophagy
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lipid droplet. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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