Protein Name:
Thioredoxin-related transmembrane protein 1
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UniprotKB/SwissProt ID: Q8VBT0 (Q8VBT0)
Gene Name:
Tmx1
Organism: Mus musculus (Mouse)
Function: Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:26246604). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (By similarity). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (By similarity). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:26246604). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:26246604). Involved in ER-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (By similarity). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (By similarity). Regulates endoplasmic reticulum-mitochondria Ca(2+) flux (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Mitochondrion membrane. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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