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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Serine/threonine-protein kinase haspin

UniprotKB/SwissProt ID: Q8TF76 (Q8TF76)

Gene Name: HASPIN

Organism: Homo sapiens (Human)

Function: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR024604 GSG2_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS

The S-nitrosylation sites of Q8TF76

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 219 EVSLDRASLP C SQEEATGGAK   
2 467 ASDAEKVYGE C SQKGPVPFSH